Long-range GABAergic neurons in the prefrontal cortex modulate behavior.
نویسندگان
چکیده
Cortical glutamatergic projections are extensively studied in behavioral neuroscience, whereas cortical GABAergic projections to downstream structures have been overlooked. A recent study by Lee and colleagues (Lee AT, Vogt D, Rubenstein JL, Sohal VS. J Neurosci 34: 11519-11525, 2014) used optogenetic and electrophysiological techniques to characterize a behavioral role for long-projecting GABAergic neurons in the medial prefrontal cortex. In this Neuro Forum, we discuss the potential implications of this study in several learning and memory models.
منابع مشابه
Neuro Forum Long-range GABAergic neurons in the prefrontal cortex modulate behavior
Bravo-Rivera C, Diehl MM, Roman-Ortiz C, Rodriguez-Romaguera J, Rosas-Vidal LE, Bravo-Rivera H, Quiñones-Laracuente K, DoMonte FH. Long-range GABAergic neurons in the prefrontal cortex modulate behavior. J Neurophysiol 114: 1357–1359, 2015. First published December 17, 2014; doi:10.1152/jn.00861.2014.—Cortical glutamatergic projections are extensively studied in behavioral neuroscience, whereas...
متن کاملComment on : A Class of GABAergic Neurons in the Prefrontal Cortex
Comment on: A Class of GABAergic Neurons in the Prefrontal Cortex Sends Long1 Range Projections to the Nucleus Accumbens and Elicits Acute Avoidance 2 Behavior 3 Lee AT, Vogt D, Rubenstein JL, Sohal VS 4 5 J Neurosci. 2014 Aug 27; 34(35):11519-25 6 7 8 Long-range GABAergic neurons in the prefrontal cortex modulate behavior 9 10 11 Christian Bravo-Rivera*, Maria M. Diehl*, Ciorana Roman-Ortiz*, ...
متن کاملA class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior.
GABAergic projections from the neocortex to subcortical structures have been poorly characterized. Using Dlxi12b-Cre mice, we found anatomical evidence for GABAergic neurons that project from the mouse medial prefrontal cortex (mPFC) to multiple subcortical targets. We used a combination of patch-clamp electrophysiology, optogenetics, and pharmacology to confirm that Dlxi12b-labeled projections...
متن کاملEffect of Trigonelline on Dendritic Morphology in the Hippocampus and Prefrontal Cortex in Streptozotocin-Induced Diabetic Rats
Introduction: Diabetes mellitus causes adverse changes in the neurological morphology of the hippocampus and prefrontal cortex of the brain by increasing oxidative stress. Trigonelline has antihyperglycemic effects and can inhibit oxidative stress. The aim of this study was to evaluate the protective effect of trigonelline on dendritic changes in hippocampal and prefrontal cortex neurons in dia...
متن کاملLong-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex.
The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of neurophysiology
دوره 114 3 شماره
صفحات -
تاریخ انتشار 2015